Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.78 |
| ▸ | HTR3A | P46098 | 8/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611923 | 0.88 | HRH4 (1.00) | HRH4HTR3AHRH1 | |
| SCHEMBL3614076 | 0.81 | HRH4 (1.00) | HRH4HTR3AHRH1 | |
| SCHEMBL438331 | 0.80 | HRH4 (0.79) | HRH4HTR3AKDM4EALDH1A1NPSR1 | |
| SCHEMBL3639044 | 0.78 | KDM4E (0.84) | HRH4HTR3AKDM4EGAAHSD17B10 | |
| SCHEMBL3639040 | 0.78 | KDM4E (0.84) | HRH4HTR3AKDM4EGAAHSD17B10 | |
| SCHEMBL3602282 | 0.77 | HRH4 (1.00) | HRH4HTR3AHRH1 | |
| SCHEMBL3606871 | 0.77 | HTR3A (1.00) | HRH4HTR3AHRH1 | |
| Hydrochloric Acid SCHEMBL3638417 | 0.77 | KDM4E (0.83) | HRH4HTR3AKDM4EGAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL3638419 | 0.77 | KDM4E (0.83) | HRH4HTR3AKDM4EGAAHSD17B10 | |
| SCHEMBL29415992 | 0.77 | KDM4E (1.00) | HTR3AKDM4EGAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016293-A1 | Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use | VERENIGING VOOR CHRISTELIJK, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016293-A1 | Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use | HRH4, HRH3, HRH2 | HRH4 1/4885HTR3A 137/4885KDM4E 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.