Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.48 |
| ▸ | EGFR | P00533 | 9/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610447 | 0.89 | ERBB2 (0.49) | ERBB2EGFRERBB4 | |
| SCHEMBL3620689 | 0.87 | ERBB2 (0.50) | ERBB2EGFRERBB4 | |
| SCHEMBL4171648 | 0.86 | ERBB2 (0.64) | ERBB2EGFR | |
| SCHEMBL3617722 | 0.83 | ERBB2 (0.56) | ERBB2EGFRERBB4 | |
| SCHEMBL5258335 | 0.83 | ERBB2 (0.56) | ERBB2EGFRERBB4 | |
| SCHEMBL3616794 | 0.82 | ERBB2 (0.59) | ERBB2EGFRERBB4 | |
| SCHEMBL4032512 | 0.81 | EGFR (0.69) | ERBB2EGFR | |
| SCHEMBL3609780 | 0.79 | ERBB2 (0.52) | ERBB2EGFRERBB4 | |
| SCHEMBL4187185 | 0.77 | ERBB2 (0.62) | ERBB2EGFRERBB4 | |
| SCHEMBL4203629 | 0.76 | ERBB2 (0.78) | ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029696-A1 | INDOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | US | disclosed |
| CN-101171245-A | Indolylamino quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2008-04-30 | — | — | CN | disclosed |
| EP-1858885-A1 | INDOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006092574-A1 | INDOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029696-A1 | INDOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ERBB2, ABL1, MKI67 | ERBB2 1/4885EGFR 4/4885ERBB4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.