Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 19/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173454 | 0.89 | ERBB2 (0.63) | ERBB2EGFRKCNH2 | |
| SCHEMBL4187185 | 0.87 | ERBB2 (0.62) | ERBB2EGFRKCNH2 | |
| SCHEMBL4180207 | 0.87 | ERBB2 (0.63) | ERBB2EGFR | |
| SCHEMBL3602871 | 0.86 | ERBB2 (0.48) | ERBB2EGFR | |
| SCHEMBL3377757 | 0.85 | ERBB2 (0.78) | ERBB2EGFRKCNH2 | |
| SCHEMBL4171631 | 0.83 | ERBB2 (0.65) | ERBB2EGFRKCNH2 | |
| SCHEMBL4177522 | 0.83 | ERBB2 (0.64) | ERBB2EGFRKCNH2 | |
| SCHEMBL4072543 | 0.82 | ERBB2 (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL3376309 | 0.80 | ERBB2 (0.70) | ERBB2EGFRKCNH2 | |
| SCHEMBL3380050 | 0.80 | ERBB2 (0.70) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137615-A1 | INDAZOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | US | disclosed |
| EP-1858884-A1 | INDAZOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006092573-A1 | INDAZOLYLAMINO QIONAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137615-A1 | INDAZOLYLAMINO QUINAZOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ERBB2, ABL1, ERBB3 | ERBB2 1/4885EGFR 5/4885KCNH2 3541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.