Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105055 | 0.92 | CENPE (0.45) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3228885 | 0.91 | CENPE (0.46) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL2102628 | 0.91 | CENPE (0.46) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL13161873 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3228894 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3461049 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3462475 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3213587 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL2617427 | 0.90 | CENPE (0.47) | CENPETAS1R3TAS1R1KIFC1RORC | |
| SCHEMBL3234840 | 0.89 | CENPE (0.44) | CENPETAS1R3TAS1R1KIFC1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582682-A1 | METHODS OF TREATING LUNG DISEASE | Cytokinetics, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2012009097-A1 | METHODS OF TREATING LUNG DISEASE | CYTOKINETICS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |