Sugi Predict

Sugi Predict / Targets / CENPE

CENPE

Centromere-associated protein E · Q02224 · CENPE on Sugi Atlas →

2,064 patent compounds predicted against CENPE, 1,227 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Gsk-923295A Gsk-923295A (SCHEMBL368558) 1.00 3/20
Gsk-923295A Gsk-923295A (SCHEMBL1492164) 1.00 3/20
Gsk-923295A Gsk-923295A (SCHEMBL2101077) 1.00 3/20
Gsk-923295A Gsk-923295A (SCHEMBL3461341) 1.00 3/20
SCHEMBL2105447 SCHEMBL2105447 0.86 3/20
SCHEMBL3461806 SCHEMBL3461806 0.86 3/20
SCHEMBL2106041 SCHEMBL2106041 0.85 3/20
SCHEMBL3463318 SCHEMBL3463318 0.85 3/20
SCHEMBL360380 SCHEMBL360380 0.85 3/20
SCHEMBL2106962 SCHEMBL2106962 0.85 3/20
SCHEMBL3228640 SCHEMBL3228640 0.85 3/20
SCHEMBL3228657 SCHEMBL3228657 0.85 3/20
SCHEMBL3462519 SCHEMBL3462519 0.85 3/20
SCHEMBL2106057 SCHEMBL2106057 0.84 3/20
SCHEMBL3223481 SCHEMBL3223481 0.84 3/20
SCHEMBL3223492 SCHEMBL3223492 0.84 3/20
SCHEMBL2104627 SCHEMBL2104627 0.83 3/20
SCHEMBL2105346 SCHEMBL2105346 0.83 3/20
SCHEMBL3462723 SCHEMBL3462723 0.83 3/20
SCHEMBL362745 SCHEMBL362745 0.81 3/20

Clinical trials — most relevant to CENPE by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients PHASE3UNKNOWN
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers PHASE1/PHASE2COMPLETED
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ PHASE2ACTIVE_NOT_RECRUITING
Study With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian Cancer PHASE2COMPLETED
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer PHASE1COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel PHASE1COMPLETED
AZD1775 for Advanced Solid Tumors PHASE1COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
PCM1-JAK2 in Therapy Related Neoplasms nanUNKNOWN
Cancer Markers Associated With Occupational Exposure to Trichloroethylene nanCOMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature. nanUNKNOWN
Importance of the Microtubule Cytoskeleton in Oocyte Competence nanCOMPLETED
Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card nanCOMPLETED
Natural History Study of Smith-Magenis Syndrome nanACTIVE_NOT_RECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
PCD New Gene Discovery nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease nanCOMPLETED
A Study of the Genetic Analysis of Brain Disorders nanCOMPLETED
Vitreous Proteomics of Patients Suffering From Pseudoexfoliation Syndrome nanACTIVE_NOT_RECRUITING
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome nanCOMPLETED
Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia nanCOMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Study of the Effect of Innate on the Inflammatory Response to Endotoxin nanRECRUITING
DNA Single Nucleotide Polymorphisms as Predictors of Toxicity nanUNKNOWN
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms nanUNKNOWN
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) nanUNKNOWN
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CENPE binder may also engage these)

ProteinNameSimilarity
KIF15 Kinesin-like protein KIF15 0.995 landscape →
Q6RT24 — 0.994 Q6RT24 →
P56536 — 0.994 P56536 →
P21613 — 0.993 P21613 →
Q9S7P3 — 0.993 Q9S7P3 →
P28738 — 0.993 P28738 →
Q91785 — 0.992 Q91785 →
Q498L9 — 0.992 Q498L9 →
KIF5A Kinesin heavy chain isoform 5A 0.992 landscape →
Q90640 — 0.991 Q90640 →
Q2PQA9 — 0.991 Q2PQA9 →
F4J2K4 — 0.990 F4J2K4 →
KIF5C Kinesin heavy chain isoform 5C 0.990 landscape →
Q86VH2 — 0.990 Q86VH2 →
Q2VIQ3 — 0.989 Q2VIQ3 →
P46864 — 0.989 P46864 →
P35978 — 0.989 P35978 →
KIF5B Kinesin-1 heavy chain 0.989 landscape →
P46875 — 0.989 P46875 →
Q28021 — 0.989 Q28021 →
Q62868 — 0.989 Q62868 →
F4JGP4 — 0.988 F4JGP4 →
Q5R9K7 — 0.988 Q5R9K7 →
O54874 — 0.988 O54874 →
CDC42BPA Serine/threonine-protein kinase MRCK alpha 0.988 landscape →
Q9H1H9 — 0.988 Q9H1H9 →
F4IJK6 — 0.987 F4IJK6 →
P17210 — 0.987 P17210 →
O23826 — 0.987 O23826 →
P46863 — 0.987 P46863 →