Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539204 | 0.91 | SMN1; SMN2 (0.52) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL20139379 | 0.88 | PTPN1 (0.61) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL7078292 | 0.88 | ERN1 (0.56) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL1853345 | 0.86 | LMNA (0.45) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL3607984 | 0.85 | PDCD1 (0.51) | SMN1; SMN2ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL2267469 | 0.82 | ERN1 (0.43) | SMN1; SMN2LMNAALDH1A1HPGDMAPT | |
| SCHEMBL20139381 | 0.82 | SMN1; SMN2 (0.45) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL3605301 | 0.81 | MAPT (0.45) | PTPN1SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL590803 | 0.81 | SMN1; SMN2 (0.50) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL20139428 | 0.81 | SMN1; SMN2 (0.49) | PTPN1SMN1; SMN2LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
| EP-2128138-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | SLC5A1, SLC5A2, GLP1R | PTPN1 403/4885SMN1; SMN2 4515/4885LMNA 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.