Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.68 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230398 | 0.95 | CENPE (0.65) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462432 | 0.93 | CENPE (0.69) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2104043 | 0.93 | CENPE (0.69) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462556 | 0.93 | CENPE (0.71) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3463366 | 0.93 | CENPE (0.71) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462266 | 0.91 | CENPE (0.80) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2104176 | 0.91 | CENPE (0.80) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL2105616 | 0.91 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3462793 | 0.91 | CENPE (0.68) | CENPEKIFC1ALDH1A1KDM4EMAPT | |
| SCHEMBL3224260 | 0.90 | CENPE (0.65) | CENPEKIFC1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582682-A1 | METHODS OF TREATING LUNG DISEASE | Cytokinetics, Inc. (US) | 2013-04-24 | — | — | EP | claimed |
| WO-2012009097-A1 | METHODS OF TREATING LUNG DISEASE | CYTOKINETICS, INC. (US) | 2012-01-19 | — | — | WO | claimed |