Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | FLT3 | P36888 | 6/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 5/20 | 0.34 |
| ▸ | LYN | P07948 | 5/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.34 |
| ▸ | SIK1 | P57059 | 5/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 5/20 | 0.34 |
| ▸ | SIK3 | Q9Y2K2 | 5/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359822 | 0.89 | MET (0.36) | CSF1RPDGFRBKDRPIK3CGSYK | |
| SCHEMBL358937 | 0.73 | MET (0.37) | CSF1RPDGFRBKDRFLT3PIK3CG | |
| SCHEMBL14915679 | 0.73 | MET (0.52) | ABL1MET | |
| SCHEMBL359518 | 0.73 | MET (0.52) | ABL1MET | |
| SCHEMBL361252 | 0.71 | MET (0.43) | MET | |
| SCHEMBL10283428 | 0.71 | FGFR2 (0.32) | — | |
| SCHEMBL359990 | 0.70 | MET (0.37) | KDRMET | |
| SCHEMBL360670 | 0.69 | MET (0.44) | SYKMET | |
| SCHEMBL368067 | 0.69 | MET (0.39) | CSF1RPDGFRBKDRFLT3FLT4 | |
| SCHEMBL10283429 | 0.68 | MET (0.44) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | claimed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | claimed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | claimed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | ABL1, ERBB2, MET | CSF1R 526/4885PDGFRB 64/4885KDR 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.