Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | PTAFR | P25105 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548424 | 0.76 | MAPT (0.39) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL29524321 | 0.64 | PRSS1 (0.48) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL8842473 | 0.64 | PRSS1 (0.48) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL549293 | 0.60 | MAP4K4 (0.59) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8842387 | 0.59 | MAP4K4 (0.58) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL4410892 | 0.56 | MAPK14 (0.61) | KMT2AMEN1KDM4EMAP4K4 | |
| SCHEMBL30450668 | 0.55 | NPC1 (0.50) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL29014979 | 0.55 | NPC1 (0.50) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL23236596 | 0.54 | PRKCI (0.34) | — | |
| SCHEMBL30451034 | 0.54 | CYP1A1 (0.49) | KMT2AMEN1MAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | TPD52L2, CCNT1, IDH2 | KMT2A 294/4885MEN1 123/4885MAPT 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.