Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.37 |
| ▸ | BCHE | P06276 | 10/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356082 | 0.90 | KDM4E (0.39) | ACHEBCHEPSEN1PSEN2APH1B | |
| SCHEMBL361143 | 0.86 | ALDH1A1 (0.35) | ACHEBCHEPSEN1PSEN2APH1B | |
| SCHEMBL10352841 | 0.86 | UGT1A1 (0.33) | UGT1A1KCNH2SLCO1B1 | |
| SCHEMBL363490 | 0.84 | CYP3A4 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15450622 | 0.82 | GPR6 (0.30) | — | |
| SCHEMBL362725 | 0.82 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL363539 | 0.81 | CYP3A4 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL369277 | 0.80 | UGT1A1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10279844 | 0.79 | CASR (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10279542 | 0.79 | SLC6A4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593461-B1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2016-08-17 | — | — | EP | disclosed |