Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rifabutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.72 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.72 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.72 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | SLCO1A2 | P46721 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rifabutin SCHEMBL1813946 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL17705915 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL28325467 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL41044 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL138130 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL23106966 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL36043 | 1.00 | ABCB11 (0.72) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL7778399 | 0.98 | ABCB11 (0.70) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL173466 | 0.98 | ABCB11 (0.70) | ABCB11CHRM1PTGS1ABCC4ABCC2 | |
| Rifabutin SCHEMBL155626 | 0.98 | ABCB11 (0.70) | ABCB11CHRM1PTGS1ABCC4ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15902 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-4121058-B1 | OXAZOLIDINONE COMPOUND AND ITS USE THEREOF AS AN ANTIBACTERIAL AGENT | MERCK SHARP & DOHME LLC (US) | 2026-02-18 | — | — | EP | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4469463-B1 | RIFAMYCIN DERIVATIVES FOR THE TREATMENT OF DISEASES | BioVersys AG (CH) | 2025-10-29 | — | — | EP | claimed |
| EP-3452124-B1 | HEMOSTATIC DEVICES AND METHODS OF USE | MEDTRONIC INC (US) | 2025-10-08 | — | — | EP | claimed |
| EP-4027976-B1 | RIFABUTIN COMPOSITIONS AND METHOD OF MAKING | BioVersys AG (CH) | 2025-10-01 | — | — | EP | claimed |
| EP-3452123-B1 | HEMOSTATIC DEVICES AND METHODS OF USE | MEDTRONIC INC (US) | 2025-09-24 | — | — | EP | claimed |
| EP-3965808-B1 | USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT | UNIV YEDITEPE (TR) | 2025-09-03 | — | — | EP | claimed |
| EP-3230500-B1 | METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF | TEPHA INC (US) | 2025-06-18 | — | — | EP | claimed |
| WO-2025012506-A1 | POLLEN PARTICLES AS CARRIERS FOR PULMONARY DELIVERY | UNIVERSIDADE DE SANTIAGO DE COMPOSTELA (ES) | 2025-01-16 | — | — | WO | claimed |
| WO-1989011277-A2 | PORPHYRIN AND PHTHALOCYANINE ANTIVIRAL COMPOSITIONS | GEORGIA STATE UNIVERSITY FOUNDATION, INC. (US) | 1989-11-30 | — | — | WO | claimed |
| US-4868157-A | IMMUNOLOGY | MERCK & CO., INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-4868155-A | IMMUNE SYSTEM STIMULANTS | MERCK & CO., INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-4866035-A | Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use | MERCK & CO., INC. (US) | 1989-09-12 | — | — | US | claimed |
| US-4866036-A | ENHANCE RESISTANCE TO OPPORTUNISTIC INFECTIONS IN COMBINATION WITH AIDS VIRICIDE | MERCK & CO., INC. (US) | 1989-09-12 | — | — | US | claimed |
| EP-0263873-A4 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD. | AL-SIOUFI HABIB | 1989-07-11 | — | — | EP | claimed |
| WO-1989000424-A1 | FUSIDIC ACID USEFUL IN THE TREATMENT OF AIDS | LEO PHARMACEUTICAL PRODUCTS B.V. (NL) | 1989-01-26 | — | — | WO | claimed |
| EP-0270317-A2 | Pharmaceutical compositions for the treatment of diseases caused by viruses | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1988-06-08 | — | — | EP | claimed |
| EP-0263873-A1 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD | AL-SIOUFI, Habib (US) | 1988-04-20 | — | — | EP | claimed |
| WO-1987006119-A1 | ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD | AL SIOUFI HABIB | 1987-10-22 | — | — | WO | claimed |