Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.72 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618170 | 1.00 | KEAP1 (0.72) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL1431227 | 1.00 | KEAP1 (0.72) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL4620506 | 0.98 | KEAP1 (0.74) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL27515279 | 0.95 | KEAP1 (0.69) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| Ethylene SCHEMBL27498090 | 0.92 | KEAP1 (0.65) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| Cadaverine Tartrate SCHEMBL27624850 | 0.86 | KEAP1 (0.58) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL29903954 | 0.86 | KEAP1 (0.96) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL198082 | 0.86 | KEAP1 (0.96) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL1235433 | 0.86 | KEAP1 (0.96) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL2764243 | 0.86 | KEAP1 (0.96) | KEAP1NFE2L2CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948164-A1 | PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES, LTD. (IN) | 2008-07-30 | — | — | EP | claimed |
| EP-1888525-A1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | Ranbaxy Laboratories Limited (IN) | 2008-02-20 | — | — | EP | claimed |
| WO-2007045979-A1 | PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-04-26 | — | — | WO | claimed |
| WO-2006117754-A1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-11-09 | — | — | WO | claimed |
| CN-103097340-B | Therapeutically active compositions and methods of use thereof | 安吉奥斯医药品有限公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-102089290-B | Triazole derivatives useful for the treatment of diseases | PFIZER | 2013-09-04 | — | — | CN | disclosed |
| EP-2593425-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | Agios Pharmaceuticals, Inc. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |
| CN-102089290-A | Triazole derivatives useful for the treatment of diseases | PFIZER LTD | 2011-06-08 | — | — | CN | disclosed |
| CN-100519526-C | Azabicyclo derivatives as muscarinic receptor antagonists | RANBAXY LAB LTD (IN) | 2009-07-29 | — | — | CN | disclosed |
| CN-1794985-A | Azabicyclo derivatives as muscarinic receptor antagonists | RANBAXY LAB LTD (IN) | 2006-06-28 | — | — | CN | disclosed |
| CN-1681784-A | Azabicyclo derivatives as muscarinic receptor antagonists | RANBAXY LAB LTD (IN) | 2005-10-12 | — | — | CN | disclosed |
| US-6207852-B1 | THERAPY FOR INCONTINENCE; CROHN'S DISEASE; MUSCLE RELAXANTS | BRIDGE PHARMA, INC. | 2001-03-27 | — | — | US | disclosed |
| EP-0915826-A4 | SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF | BRIDGE PHARMA INC (US) | 1999-12-29 | — | — | EP | disclosed |
| EP-0915826-A1 | SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF | Bridge Pharma, Inc. (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998000390-A1 | SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF | BRIDGE PHARMA, INC. (US) | 1998-01-08 | — | — | WO | disclosed |
| CN-1044938-A | Acetamide compound of a kind of new replacement and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-08-29 | — | — | CN | disclosed |
| EP-0383256-A2 | A novel substituted-acetamide compound and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-22 | — | — | EP | disclosed |