Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 4/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355490 | 0.84 | EIF2AK4 (0.47) | EIF2AK4FLT3AURKAGSK3AGSK3B | |
| SCHEMBL1355845 | 0.83 | EIF2AK4 (0.60) | EIF2AK4FLT3AURKAJAK2JAK3 | |
| SCHEMBL1355918 | 0.83 | EIF2AK4 (0.48) | EIF2AK4FLT3AURKAGSK3AGSK3B | |
| SCHEMBL1356177 | 0.81 | EIF2AK4 (0.47) | EIF2AK4FLT3AURKAGSK3AGSK3B | |
| SCHEMBL3587383 | 0.75 | DCLK1 (0.39) | SRCEIF2AK4FLT3AURKAJAK2 | |
| SCHEMBL1355882 | 0.73 | AURKA (0.46) | EIF2AK4AURKAGSK3BCDK1CCNB1 | |
| SCHEMBL1355988 | 0.72 | FLT3 (0.64) | EIF2AK4FLT3AURKAJAK2JAK3 | |
| SCHEMBL3588130 | 0.72 | AURKA (0.39) | EIF2AK4FLT3AURKAJAK2JAK3 | |
| SCHEMBL27766949 | 0.72 | MEN1 (0.51) | SRCEIF2AK4FLT3JAK2JAK3 | |
| SCHEMBL3587399 | 0.71 | AURKA (0.37) | WEE1SRCFLT3AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | WEE1 104/4885SRC 311/4885EIF2AK4 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.