Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605830 | 1.00 | MAPKAPK2 (0.48) | MAPKAPK2MAPTTP53AURKAJAK2 | |
| SCHEMBL13408153 | 0.93 | MAPKAPK2 (0.44) | MAPKAPK2MAPTTP53AURKAJAK2 | |
| SCHEMBL13408082 | 0.92 | MAPKAPK2 (0.46) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL3608148 | 0.91 | MAPKAPK2 (0.46) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL3608151 | 0.91 | MAPKAPK2 (0.46) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL3607125 | 0.90 | MAPKAPK2 (0.46) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL3607124 | 0.90 | MAPKAPK2 (0.46) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL13408155 | 0.90 | MAPKAPK2 (0.44) | MAPKAPK2MAPTAURKAJAK2LCK | |
| SCHEMBL3610985 | 0.89 | MAPKAPK2 (0.42) | MAPKAPK2MAPTTP53AURKAJAK2 | |
| SCHEMBL3610981 | 0.89 | MAPKAPK2 (0.42) | MAPKAPK2MAPTTP53AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | claimed |
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | SLCO1B3, SLCO1B1, SLC10A6 | MAPKAPK2 4395/4885MAPT 2170/4885TP53 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.