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Sugi Predict / Targets / SLC10A6

SLC10A6

Sodium-dependent organic anion transporter · Q3KNW5 · SLC10A6 on Sugi Atlas →

1,842 patent compounds predicted against SLC10A6, 1,537 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL5115455 SCHEMBL5115455 0.88 3/20
SCHEMBL491625 SCHEMBL491625 0.72 3/20
SCHEMBL491711 SCHEMBL491711 0.72 3/20
SCHEMBL5114385 SCHEMBL5114385 0.69 3/20
SCHEMBL5126107 SCHEMBL5126107 0.69 3/20
SCHEMBL5126790 SCHEMBL5126790 0.69 3/20
SCHEMBL5111324 SCHEMBL5111324 0.69 3/20
SCHEMBL5119272 SCHEMBL5119272 0.67 3/20
SCHEMBL5126770 SCHEMBL5126770 0.67 3/20
SCHEMBL5119180 SCHEMBL5119180 0.65 3/20
SCHEMBL5119260 SCHEMBL5119260 0.65 3/20
SCHEMBL490913 SCHEMBL490913 0.64 3/20
SCHEMBL492067 SCHEMBL492067 0.64 3/20
SCHEMBL492482 SCHEMBL492482 0.64 3/20
SCHEMBL5119313 SCHEMBL5119313 0.64 3/20
SCHEMBL5117162 SCHEMBL5117162 0.63 3/20
SCHEMBL5114776 SCHEMBL5114776 0.62 3/20
SCHEMBL5115416 SCHEMBL5115416 0.62 3/20
SCHEMBL5111523 SCHEMBL5111523 0.61 3/20
SCHEMBL5125728 SCHEMBL5125728 0.61 3/20

Clinical trials — most relevant to SLC10A6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Genetic Basis for Variation in the Renal Elimination of Metformin PHASE4COMPLETED
Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use PHASE4COMPLETED
Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects PHASE4COMPLETED
Effect of Age on the Renal Clearance of Adefovir PHASE4WITHDRAWN
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) PHASE4COMPLETED
Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist® PHASE1/PHASE2COMPLETED
Intrathecal Gene Therapy For SLC13A5 Citrate Transporter Disorder PHASE1/PHASE2NOT_YET_RECRUITING
Effect of, OAT3, on the Renal Secretion of Cefotaxime PHASE1COMPLETED
Open Label Pharmacokinetic-Pharmacogenetic Study on Polymorphisms in the Organic Cation Transporter OCT1 PHASE1COMPLETED
Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics PHASE1COMPLETED
Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer EARLY_PHASE1UNKNOWN
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I EARLY_PHASE1COMPLETED
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals nanENROLLING_BY_INVITATION
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only nanENROLLING_BY_INVITATION
The Furosemide Stress Test, Electrolytes Response and Renal Index in Critically Ill Patients nanCOMPLETED
Influence of OCTN2 Variants on Carnitine Status and Plasma Triglycerides nanCOMPLETED
Genetics of Hyperuricemia Therapy in Hmong nanCOMPLETED
Impact of Genetics on Metformin Pharmacokinetics nanCOMPLETED
Oxalate and Citrate nanRECRUITING
Biological Collection of Kidney Cells nanUNKNOWN
Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia nanCOMPLETED
Gyrate Atrophy Ocular and Systemic Study nanACTIVE_NOT_RECRUITING
ADPKD Alterations in Hepatic Transporter Function nanCOMPLETED
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC10A6 binder may also engage these)

ProteinNameSimilarity
A6QP84 — 0.999 A6QP84 →
Q9CXB2 — 0.996 Q9CXB2 →
Q70EX6 — 0.990 Q70EX6 →
Q3UEZ8 — 0.982 Q3UEZ8 →
P09131 — 0.981 P09131 →
Q96EP9 — 0.975 Q96EP9 →
Q5PT56 — 0.975 Q5PT56 →
Q0V8N6 — 0.971 Q0V8N6 →
P26435 — 0.970 P26435 →
O08705 — 0.969 O08705 →
P21129 — 0.962 P21129 →
SLC10A1 Hepatic sodium/bile acid cotransporter 0.960 landscape →
Q60414 — 0.959 Q60414 →
SLC10A2 Ileal sodium/bile acid cotransporter 0.958 landscape →
Q8K1P8 — 0.957 Q8K1P8 →
Q9JJF9 — 0.955 Q9JJF9 →
F7B113 — 0.955 F7B113 →
D4A7H1 — 0.955 D4A7H1 →
Q8IVB4 — 0.954 Q8IVB4 →
P26434 — 0.954 P26434 →
O70324 — 0.953 O70324 →
Q8BLV3 — 0.953 Q8BLV3 →
Q8BFW9 — 0.951 Q8BFW9 →
Q5BKR2 — 0.950 Q5BKR2 →
P36021 — 0.950 P36021 →
G8XYX6 — 0.950 G8XYX6 →
Q569T7 — 0.949 Q569T7 →
P30083 — 0.949 P30083 →
Q5PT54 — 0.949 Q5PT54 →
Q5PQL3 — 0.948 Q5PQL3 →