Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403909 | 0.91 | — | — | |
| SCHEMBL789961 | 0.91 | PTGS1 (0.39) | KDM4EMAPTALOX15MAPK1ALDH1A1 | |
| SCHEMBL14414885 | 0.91 | PTGS1 (0.39) | KDM4EMAPTALOX15MAPK1ALDH1A1 | |
| SCHEMBL63679 | 0.91 | PTGS1 (0.39) | KDM4EMAPTALOX15MAPK1ALDH1A1 | |
| Propane SCHEMBL28199390 | 0.88 | PTGS1 (0.35) | PAOXTDP1TP53KDM4EUSP2 | |
| SCHEMBL9391152 | 0.88 | PTGS1 (0.35) | PAOXTDP1TP53KDM4EUSP2 | |
| SCHEMBL8343269 | 0.88 | PTGS1 (0.35) | PAOXTDP1TP53KDM4EUSP2 | |
| SCHEMBL25336178 | 0.88 | PTGS1 (0.38) | TDP1TP53KDM4EUSP2CYP3A4 | |
| SCHEMBL8463674 | 0.88 | PTGS1 (0.38) | TDP1TP53KDM4EUSP2CYP3A4 | |
| SCHEMBL9897194 | 0.88 | PTGS1 (0.38) | TDP1TP53KDM4EUSP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | claimed |
| CN-101437819-B | Pyridopyrazines and derivatives thereof as alk and c-MET inhibitors | CEPHALON INC | 2013-06-19 | — | — | CN | claimed |
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | claimed |
| CN-101437819-A | Pyridopyrazines and derivatives thereof as ALK and c-MET inhibitors | CEPHALON INC (US) | 2009-05-20 | — | — | CN | claimed |
| US-20080032972-A1 | Pyridopyrazines and derivatives thereof as alk and c-Met inhibitors | CEPHALON, INC. (US) | 2008-02-07 | — | — | US | claimed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | claimed |
| US-7026336-B1 | 4-pyridinylimidazol-2-ylhydrocarbyl amine, (thio)urea, carbamic acid or sulfonamide derivatives, e.g., (2-(4-(4-Chloro-3-methoxy-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-carbamic acid tert-butyl ester; Raf kinase inhibitors for the treatment of neurotraumatic diseases | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-04-11 | — | — | US | claimed |
| WO-2024020164-A2 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | FIREFLY BIO, INC. (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2023109942-A1 | COMPOUND-LINKER CONSTRUCTS COMPRISING NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-06-22 | — | — | WO | disclosed |
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |
| CN-101437819-B | Pyridopyrazines and derivatives thereof as alk and c-MET inhibitors | CEPHALON INC | 2013-06-19 | — | — | CN | disclosed |
| US-8080561-B2 | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors | CEPHALON, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20100048576-A1 | PYRIDOPYRAZINES AND DERIVATIVES THEREOF AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2001038324-A2 | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-31 | — | — | WO | disclosed |
| EP-1033913-A1 | ZWITTERIONIC FATTY ACID COMPOUNDS FOR ANTI-INFLAMATION | Pugliese, Peter T. (US) | 2000-09-13 | — | — | EP | disclosed |
| EP-1033913-A1 | ZWITTERIONIC FATTY ACID COMPOUNDS FOR ANTI-INFLAMATION | Pugliese, Peter T. (US) | 2000-09-13 | — | — | EP | disclosed |
| US-6114337-A | Zwitteronic-fatty acid compounds having anti-inflammatory properties | PUGLIESE PETER T (US) | 2000-09-05 | — | — | US | disclosed |
| US-6114337-A | Zwitteronic-fatty acid compounds having anti-inflammatory properties | PUGLIESE PETER T (US) | 2000-09-05 | — | — | US | disclosed |
| WO-1999027791-A1 | ZWITTERIONIC FATTY ACID COMPOUNDS FOR ANTI-INFLAMATION | PUGLIESE PETER T (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999027791-A1 | ZWITTERIONIC FATTY ACID COMPOUNDS FOR ANTI-INFLAMATION | PUGLIESE PETER T (US) | 1999-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048576-A1 | PYRIDOPYRAZINES AND DERIVATIVES THEREOF AS ALK AND c-MET INHIBITORS | ALK, MET, RET | PAOX 2423/4885TDP1 2394/4885TP53 464/4885 |
| US-20080032972-A1 | Pyridopyrazines and derivatives thereof as alk and c-Met inhibitors | ALK, MET, RET | PAOX 2423/4885TDP1 2394/4885TP53 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.