Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607396 | 1.00 | HRH4 (0.52) | HRH4SMYD3NSD2SETD2PARP1 | |
| Trifluoroacetic Acid SCHEMBL3599367 | 0.94 | HRH4 (0.47) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3615229 | 0.93 | CDK2 (0.53) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3614361 | 0.93 | CDK2 (0.53) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3606357 | 0.86 | SMYD3 (0.69) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3606352 | 0.86 | SMYD3 (0.69) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3607953 | 0.86 | SMYD3 (0.69) | HRH4SMYD3NSD2SETD2PARP1 | |
| SCHEMBL3611824 | 0.84 | SMYD3 (0.47) | SMYD3NSD2SETD2PARP1MLLT1 | |
| SCHEMBL3611827 | 0.84 | SMYD3 (0.47) | SMYD3NSD2SETD2PARP1MLLT1 | |
| Trifluoroacetic Acid SCHEMBL3596233 | 0.82 | SMYD3 (0.61) | HRH4SMYD3NSD2SETD2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | HRH4 396/4885SMYD3 811/4885NSD2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.