Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 3/20 | 0.50 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017856 | 0.88 | MCL1 (0.66) | ROCK1THRBMCL1RXFP1MEN1 | |
| SCHEMBL3608218 | 0.80 | MCL1 (0.54) | ROCK1THRBMCL1RXFP1MEN1 | |
| SCHEMBL14626728 | 0.79 | PTGDR2 (0.59) | ROCK1THRBMCL1RXFP1MEN1 | |
| SCHEMBL29581946 | 0.77 | MCL1 (0.67) | ROCK1MCL1MEN1NPC1RAB9A | |
| SCHEMBL1093913 | 0.77 | MCL1 (0.67) | ROCK1MCL1MEN1NPC1RAB9A | |
| SCHEMBL13406296 | 0.77 | KDM4E (0.56) | MEN1NPC1RAB9AKMT2AGRM4 | |
| SCHEMBL14591857 | 0.76 | PTGDR2 (0.56) | ROCK1THRBMCL1RXFP1MEN1 | |
| SCHEMBL6989729 | 0.76 | ROCK1 (0.53) | ROCK1THRBMCL1RXFP1MEN1 | |
| SCHEMBL30525414 | 0.76 | MCL1 (0.65) | ROCK1MCL1MEN1NPC1RAB9A | |
| SCHEMBL2330423 | 0.75 | ROCK1 (0.52) | ROCK1THRBMCL1RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273736-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES (US) | 2012-09-25 | — | — | US | disclosed |
| US-20100069371-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069371-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABL1, ERBB2, LCK | ROCK1 621/4885THRB 806/4885MCL1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.