Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642674 | 0.87 | TP53 (0.62) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL7414681 | 0.87 | TP53 (0.62) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL13349682 | 0.83 | TP53 (0.36) | TP53L3MBTL1 | |
| SCHEMBL8277704 | 0.80 | KMT2A (0.40) | TP53L3MBTL1TDP1KMT2A | |
| SCHEMBL3587342 | 0.79 | TP53 (0.51) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL10642729 | 0.78 | TP53 (0.56) | TP53L3MBTL1ACEFOLH1AKR1C4 | |
| SCHEMBL3607831 | 0.77 | TP53 (0.50) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL17964289 | 0.77 | TP53 (0.50) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL3605160 | 0.77 | TP53 (0.50) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL10639478 | 0.76 | FOLH1 (0.53) | TP53L3MBTL1ACEFOLH1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728022-B2 | (3-phenyl-1-{1-[4-(trifluoromethyl)phenyl]butyl}-4,5,6,7-tetrahydro-1H-indol-7-yl)acetic acid, used for treating diseases associated with the deposition of beta -amyloid peptide in the brain | MERCK SHARP & DOHME LTD. (GB) | 2010-06-01 | — | — | US | disclosed |