Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 4/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414681 | 0.87 | TP53 (0.62) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL10642674 | 0.87 | TP53 (0.62) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL22273295 | 0.81 | BRD4 (0.40) | TP53L3MBTL1ACEKMT2A | |
| SCHEMBL22264486 | 0.81 | BRD4 (0.40) | TP53L3MBTL1ACEKMT2A | |
| SCHEMBL9968593 | 0.79 | KMT2A (0.39) | TP53L3MBTL1KMT2ATSHRALDH1A1 | |
| SCHEMBL3608667 | 0.79 | TP53 (0.51) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL10642729 | 0.78 | TP53 (0.56) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL17964252 | 0.78 | TP53 (0.36) | TP53L3MBTL1ITGB3ITGB2ITGB1 | |
| SCHEMBL17964289 | 0.77 | TP53 (0.50) | TP53L3MBTL1ACEFOLH1ITGB3 | |
| SCHEMBL3607831 | 0.77 | TP53 (0.50) | TP53L3MBTL1ACEFOLH1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8203004-B2 | Tetrahydroindole derivatives for treatment of alzheimer's disease | MERCK, SHARP & DOHME LIMITED (GB) | 2012-06-19 | — | — | US | disclosed |
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-21 | — | — | US | disclosed |
| EP-1948603-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054739-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | BACE1, BACE2, PSEN2 | TP53 3184/4885L3MBTL1 3835/4885ACE 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.