Sugi Predict

Sugi Predict / Compounds / SCHEMBL3610027

SCHEMBL3610027

SCHEMBL3610027

Clc1cc(Cl)cc(Cc2nnc(Cl)c3ccccc23)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 9/20 0.43
▸ FLT1 P17948 8/20 0.43
▸ PDGFRB P09619 3/20 0.43
▸ KIT P10721 2/20 0.43
▸ CIT O14578 1/20 0.43
▸ EGFR P00533 1/20 0.43
▸ HLA-A P04439 1/20 0.43
▸ CSF1R P07333 1/20 0.43
▸ RET P07949 1/20 0.43
▸ PDGFRA P16234 1/20 0.43
▸ RPS6KB1 P23443 1/20 0.43
▸ FLT4 P35916 1/20 0.43
▸ FRK P42685 1/20 0.43
▸ CDK8 P49336 1/20 0.43
▸ DDR1 Q08345 1/20 0.43
▸ STK3 Q13188 1/20 0.43
▸ PTK6 Q13882 1/20 0.43
▸ MAP3K19 Q56UN5 1/20 0.43
▸ CDK19 Q9BWU1 1/20 0.43
▸ MAP3K20 Q9NYL2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2310333 0.84 NPSR1 (0.56) KDRFLT1PDGFRBKITCIT
SCHEMBL26907184 0.82 KDR (0.46) KDRFLT1PDGFRBKITCIT
SCHEMBL27900008 0.81 KDR (0.42) KDRFLT1PDGFRBKITCIT
SCHEMBL905518 0.79 FLT1 (0.59) KDRFLT1PDGFRBKITCIT
SCHEMBL30773496 0.79 FLT1 (0.59) KDRFLT1PDGFRBKITCIT
SCHEMBL20420613 0.79 SSTR2 (0.31) KDRFLT1PDGFRBKITCIT
SCHEMBL7115917 0.78 SMO (0.44) KDRFLT1PDGFRBKITCIT
SCHEMBL5332250 0.76 FLT1 (0.62) KDRFLT1PDGFRBKITCIT
SCHEMBL4814035 0.75 FLT1 (0.65) KDRFLT1PDGFRBKITCIT
SCHEMBL5279165 0.75 CYP11B1 (0.47) KDRFLT1PDGFRBKITCIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137162-B1 ORGANIC COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2018-08-01 — — EP disclosed
US-8536168-B2 Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway NOVARTIS AG (CH) 2013-09-17 — — US disclosed
US-8536168-B2 Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway NOVARTIS AG (CH) 2013-09-17 — — US disclosed
US-8536168-B2 Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway NOVARTIS AG (CH) 2013-09-17 — — US disclosed
US-20100069368-A1 Organic Compounds and Their Uses NOVARTIS AG (CH) 2010-03-18 — — US disclosed
US-20100069368-A1 Organic Compounds and Their Uses NOVARTIS AG (CH) 2010-03-18 — — US disclosed
US-20100069368-A1 Organic Compounds and Their Uses NOVARTIS AG (CH) 2010-03-18 — — US disclosed
EP-2137162-A1 ORGANIC COMPOUNDS AND THEIR USES Novartis Ag (CH) 2009-12-30 — — EP disclosed
WO-2008110611-A1 ORGANIC COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2008-09-18 — — WO disclosed
WO-2008110611-A1 ORGANIC COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2008-09-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069368-A1 Organic Compounds and Their Uses SHH, GLI1, VHL KDR 3069/4885FLT1 2643/4885PDGFRB 1273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.