Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 8/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914610 | 0.87 | FLT1 (0.55) | FLT1GAAMAPK1MEN1KMT2A | |
| SCHEMBL4814640 | 0.86 | FLT1 (0.48) | FLT1GAAMAPK1MAPTRAB9A | |
| SCHEMBL8527636 | 0.85 | FLT1 (0.57) | FLT1GAAMAPK1MEN1KMT2A | |
| SCHEMBL4817310 | 0.85 | CYP2A6 (0.49) | FLT1CYP1A2HRH4HRH3CYP2D6 | |
| SCHEMBL2310333 | 0.83 | NPSR1 (0.56) | FLT1MEN1KMT2AKDRPDGFRB | |
| SCHEMBL30773496 | 0.82 | FLT1 (0.59) | FLT1KDRPDGFRBKITCIT | |
| SCHEMBL905518 | 0.82 | FLT1 (0.59) | FLT1KDRPDGFRBKITCIT | |
| SCHEMBL7670317 | 0.81 | FLT1 (0.55) | FLT1GAAMAPK1MEN1KMT2A | |
| SCHEMBL10217403 | 0.79 | MEN1 (0.61) | FLT1GAAMAPK1MEN1KMT2A | |
| SCHEMBL5279165 | 0.78 | CYP11B1 (0.47) | FLT1GAAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3106875-A | — | — | None | — | — | JP | disclosed |
| CN-101184395-A | Diarylamine-containing compounds and compositions, and their use as modulators of steroid hormone nuclear receptors | IRM LLC (BM) | 2008-05-21 | — | — | CN | disclosed |
| EP-1865775-A1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM, LLC (BM) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006108107-A1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2006-10-12 | — | — | WO | disclosed |
| CN-1151136-C | Condensed pyridazine compound | ������������ʽ���� | 2004-05-26 | — | — | CN | disclosed |
| CN-1135210-A | Fused pyridazine compound | EISAI CO LTD (JP) | 1996-11-06 | — | — | CN | disclosed |
| JP-H03106875-A | 1-(3-PYRIDYLMETHYL)PHTHALAZINE DERIVATIVE | MORISHITA PHARMACEUT CO LTD | 1991-05-07 | — | — | JP | disclosed |