Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610040 | 1.00 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3598975 | 0.89 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3603277 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3603286 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3609068 | 0.84 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3604328 | 0.84 | TSHR (0.35) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3604320 | 0.84 | TSHR (0.35) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3609063 | 0.84 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3604317 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3604938 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301258-B2 | Benzende sulfonamide derivatives as HIV integrase inhibitors | HOWARD UNIVERSITY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170008839-A1 | BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS | HOWARD UNIVERSITY (US) | 2017-01-12 | — | — | US | disclosed |
| US-20160347739-A1 | 5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS | HOWARD UNIVERSITY (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2015130958-A1 | 5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS | HOWARD UNIVERSITY (US) | 2015-09-03 | — | — | WO | disclosed |
| US-20100048540-A1 | Heterocyclic N-Oxides as Hypoxic Selective Protein Kinase Inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| US-20100016396-A1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
| EP-2128138-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
| US-20080234276-A1 | Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors | SENTINEL ONCOLOGY LIMITED (UK) | 2008-09-25 | — | — | US | disclosed |
| EP-1585749-B1 | DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1947102-A1 | Compositions comprising diazepinoindole derivatives as kinase inhibitors | Pfizer, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2002062293-A2 | COUMARIN COMPOUNDS AS MICROTUBULE STABILIZING AGENTS AND THERAPEUTIC USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-08-15 | — | — | WO | disclosed |
| EP-1215208-A2 | 4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases | Agouron Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001079198-A9 | PYRAZOLES FOR INHIBITING PROTEIN KINASE | AGOURON PHARMA (US) | 2002-05-16 | — | — | WO | disclosed |
| US-20020049215-A1 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases | AGOURON PHARMACEUTICALS, INC. | 2002-04-25 | — | — | US | disclosed |
| WO-2002012250-A2 | PYRAZOLE-THIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND METHODS OF THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| US-20020006952-A1 | Compounds, pharmaceutical compositions, and methods for inhibiting protein kinases | LIGHPOINTE COMMUNICATION, INC. | 2002-01-17 | — | — | US | disclosed |
| WO-2001079198-A1 | PYRAZOLES FOR INHIBITING PROTEIN KINASE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |
| WO-2001053268-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |
| EP-1056732-A2 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999021845-A2 | 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049215-A1 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases | CDK4, CCNK, CDK2 | KDM4E 1950/4885ALDH1A1 2325/4885HSD17B10 3379/4885 |
| US-20170008839-A1 | BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS | NR2E3, NR2E1, PIM3 | KDM4E 114/4885ALDH1A1 2073/4885HSD17B10 1414/4885 |
| US-20100048540-A1 | Heterocyclic N-Oxides as Hypoxic Selective Protein Kinase Inhibitors | HIF1AN, HIF1A, HYOU1 | KDM4E 1024/4885ALDH1A1 2382/4885HSD17B10 2370/4885 |
| US-20160347739-A1 | 5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS | INTS9, API5, IMPDH1 | KDM4E 58/4885ALDH1A1 1683/4885HSD17B10 1406/4885 |
| US-20080234276-A1 | Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors | HIF1AN, HIF1A, CDK2 | KDM4E 962/4885ALDH1A1 3402/4885HSD17B10 2984/4885 |
| US-10301258-B2 | Benzende sulfonamide derivatives as HIV integrase inhibitors | NR2E3, NR2E1, PIM3 | KDM4E 114/4885ALDH1A1 2073/4885HSD17B10 1414/4885 |
| US-20100016396-A1 | PYRAZOLE COMPOUND | SLC5A1, SLC5A2, GLP1R | KDM4E 2049/4885ALDH1A1 365/4885HSD17B10 390/4885 |
| US-20020006952-A1 | Compounds, pharmaceutical compositions, and methods for inhibiting protein kinases | CDK3, CCNK, CDK1 | KDM4E 1636/4885ALDH1A1 3414/4885HSD17B10 4382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.