Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ornithine Aketoglutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL27955723 | 1.00 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL8919110 | 1.00 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL28321586 | 1.00 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL755884 | 1.00 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Ornithine SCHEMBL361185 | 1.00 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL14656074 | 0.98 | GSR (0.67) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL27858630 | 0.98 | GSR (0.67) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Ornithine SCHEMBL14656075 | 0.98 | GSR (0.67) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL1425215 | 0.94 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL1425217 | 0.94 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119846123-A | Tryptophan composition and application thereof in preparation of products for screening hepatic encephalopathy | 首都医科大学附属北京世纪坛医院 | 2025-04-18 | — | — | CN | disclosed |
| CN-108024968-B | Effervescent preparation of ornithine aspartate | 赢创运营有限公司 | 2022-07-05 | — | — | CN | disclosed |
| EP-3965659-A1 | METHODS OF ASSESSING AND TREATING HEPATIC ENCEPHALOPATHY | Ocera Therapeutics, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |
| EP-2911659-A2 | DRUG COMBINATIONS AND USES | Biocopea Limited (GB) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014064191-A2 | DRUG COMBINATIONS AND USES | BIOCOPEA LIMITED (GB) | 2014-05-01 | — | — | WO | disclosed |
| EP-2593541-A1 | METHODS OF TREATING HEPATORENAL SYNDROME AND HEPATIC ENCEPHALOPATHY WITH THROMBOXANE-A2 RECEPTOR ANTAGONISTS | Cumberland Emerging Technologies, Inc (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009545-A1 | METHODS OF TREATING HEPATORENAL SYNDROME AND HEPATIC ENCEPHALOPATHY WITH THROMBOXANE-A2 RECEPTOR ANTAGONISTS | CUMBERLAND EMERGING TECHNOLOGIES, INC (US) | 2012-01-19 | — | — | WO | disclosed |
| US-5629002-A | THIOCYANATES IN SYNERGISTIC COMBINATION WITH ESTROGENS, SULFUR, SULFIDES, VASODILATORS, PROTEIN HYDROLYZATES, AMINO ACIDS, CARBOXYLIC ACIDS, VITAMINS | WEUFFEN WOLFGANG (DE) | 1997-05-13 | — | — | US | disclosed |