Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 8/20 | 0.45 |
| ▸ | GUCY1A2 | P33402 | 8/20 | 0.45 |
| ▸ | GUCY1A1 | Q02108 | 8/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 8/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624888 | 0.91 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3997938 | 0.88 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3629056 | 0.87 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3628181 | 0.87 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3626338 | 0.87 | S1PR1 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3238565 | 0.86 | GUCY1B2 (0.48) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3627113 | 0.86 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3628362 | 0.86 | GUCY1B2 (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3624902 | 0.85 | KDM4E (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3618939 | 0.85 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |