Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.40 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628362 | 0.95 | GUCY1B2 (0.42) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 | |
| SCHEMBL3624888 | 0.92 | GUCY1B2 (0.47) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 | |
| SCHEMBL3627146 | 0.92 | GUCY1B2 (0.44) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 | |
| SCHEMBL3626258 | 0.90 | GUCY1B2 (0.39) | KDM4EGUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3997687 | 0.88 | SCN9A (0.44) | NEK2GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3616728 | 0.85 | GUCY1B2 (0.45) | KDM4EGUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3624521 | 0.85 | GUCY1B2 (0.43) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 | |
| SCHEMBL3627415 | 0.85 | HCRTR1 (0.44) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 | |
| SCHEMBL3618939 | 0.84 | GUCY1B2 (0.45) | KDM4ENEK2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3628719 | 0.84 | GUCY1B2 (0.44) | KDM4EALDH1A1NEK2GUCY1B2GUCY1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |