Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.40 |
| ▸ | MLYCD | O95822 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187761 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL4609823 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL11371728 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL13974786 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL7101194 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL2080757 | 0.76 | AR (0.50) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL3624298 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL7102669 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL11245521 | 0.76 | AR (0.46) | SMN1; SMN2MEN1KMT2AARALOX15 | |
| SCHEMBL2754718 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AARALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392567-A1 | BENZOTHIAZINE DERIVATIVES AND THEIR USE AS LXR MODULATORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| US-7741317-B2 | LXR modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070093470-A1 | LXR modulators | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093470-A1 | LXR modulators | NR1H2, NR1H3, RXRB | SMN1; SMN2 4731/4885MEN1 3861/4885KMT2A 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.