Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 3/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030530 | 1.00 | ADORA1 (0.59) | ADORA1PLK1MAPK1HDAC8HDAC6 | |
| SCHEMBL1033923 | 0.88 | IKBKB (0.59) | ADORA1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL3653069 | 0.88 | PLK1 (0.55) | ADORA1PLK1MAPK1HDAC8HDAC6 | |
| SCHEMBL5819449 | 0.85 | ADORA1 (0.52) | ADORA1PLK1MAPK1HDAC8HDAC6 | |
| SCHEMBL1028968 | 0.85 | MAP4K4 (0.55) | MAPK1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL1033626 | 0.85 | CDK1 (0.53) | MAPK1IKBKBMAPK8MAPK9MAPK10 | |
| SCHEMBL1032138 | 0.84 | IKBKB (0.76) | MAPK1HDAC8HDAC6IKBKBMAPK8 | |
| SCHEMBL5823374 | 0.83 | ADORA1 (0.53) | ADORA1PLK1MAPK1HDAC8HDAC6 | |
| SCHEMBL5815500 | 0.83 | TGFBR1 (0.54) | ADORA1PLK1MAPK1HDAC8HDAC6 | |
| SCHEMBL2389822 | 0.83 | IKBKB (0.55) | PLK1MAPK1IKBKBMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151747-A1 | PYRIMINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |