Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.84 |
| ▸ | CNR2 | P34972 | 18/20 | 0.84 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.84 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.84 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.84 |
| ▸ | EGFR | P00533 | 1/20 | 0.84 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.84 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.84 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.84 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.84 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.84 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.84 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.84 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthyridinone SCHEMBL762298 | 0.92 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3623205 | 0.91 | CNR1 (0.79) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL5315906 | 0.91 | CNR1 (0.76) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3621932 | 0.88 | CNR1 (0.83) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3624392 | 0.88 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3627613 | 0.88 | CNR1 (0.84) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3623463 | 0.88 | CNR1 (0.82) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3616208 | 0.87 | CNR1 (0.91) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3625557 | 0.87 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3620209 | 0.86 | CNR1 (0.80) | CNR1CNR2GABRA1ADRA2CSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728141-B2 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-06-01 | — | — | US | claimed |
| EP-1682550-B1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2009-12-23 | — | — | EP | claimed |
| JP-2007510649-A | — | — | 2007-04-26 | — | — | JP | claimed |
| US-20070032517-A1 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. | 2007-02-08 | — | — | US | claimed |
| EP-1682550-A4 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1682550-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | Merck & Co., Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047285-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | claimed |
| US-7728141-B2 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728141-B2 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728141-B2 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-06-01 | — | — | US | disclosed |
| EP-1682550-B1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2009-12-23 | — | — | EP | disclosed |
| EP-1682550-B1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2009-12-23 | — | — | EP | disclosed |
| US-20070032517-A1 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. | 2007-02-08 | — | — | US | disclosed |
| US-20070032517-A1 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. | 2007-02-08 | — | — | US | disclosed |
| US-20070032517-A1 | Substituted naphthyridinone derivatives | MERCK SHARP & DOHME CORP. | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032517-A1 | Substituted naphthyridinone derivatives | CNR1, CNR2, MAG | CNR1 1/4885CNR2 2/4885GABRA1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.