Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.76 |
| ▸ | CNR2 | P34972 | 18/20 | 0.76 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.71 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.71 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.71 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.63 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3620523 | 0.91 | CNR1 (0.84) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3622708 | 0.86 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL13593624 | 0.86 | CNR1 (0.87) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3619245 | 0.86 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3626355 | 0.84 | CNR1 (0.86) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL4407145 | 0.83 | CNR1 (0.84) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3623205 | 0.83 | CNR1 (0.79) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3620209 | 0.83 | CNR1 (0.80) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| Naphthyridinone SCHEMBL762298 | 0.83 | CNR1 (1.00) | CNR1CNR2GABRA1ADRA2CSLC6A3 | |
| SCHEMBL3622284 | 0.82 | CNR1 (0.70) | CNR1CNR2GABRA1ADRA2CSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510649-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682550-A4 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1682550-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | Merck & Co., Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047285-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | claimed |
| EP-1682550-A4 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO INC (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1682550-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | Merck & Co., Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047285-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | disclosed |