Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3621286 | 0.92 | CHRNA7 (0.68) | CHRNA7MEN1TSHRKMT2ALMNA | |
| Succinic Acid SCHEMBL3628651 | 0.84 | CHRNA7 (0.56) | CHRNA7MEN1TSHRKMT2A | |
| Succinic Acid SCHEMBL3628654 | 0.82 | CHRNA7 (0.48) | CHRNA7MEN1TSHRKMT2ALMNA | |
| Bromide SCHEMBL11249831 | 0.78 | CHRNA7 (0.93) | CHRNA7 | |
| Water SCHEMBL9979643 | 0.78 | CHRNA7 (0.93) | CHRNA7 | |
| SCHEMBL10884820 | 0.78 | CHRNA7 (0.93) | CHRNA7 | |
| Iodide SCHEMBL5050443 | 0.78 | CHRNA7 (0.93) | CHRNA7 | |
| Bicarbonate SCHEMBL21331675 | 0.65 | TSHR (0.39) | MEN1TSHRKMT2ALMNA | |
| Bicarbonate SCHEMBL6365374 | 0.63 | TSHR (0.38) | MEN1TSHRKMT2ALMNA | |
| Bicarbonate SCHEMBL19411368 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100085683-A1 | ELECTROLYTE, ELECTROLYTIC SOLUTION, AND ELECTROCHEMICAL DEVICE USING THE SAME | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2010-04-08 | — | — | US | disclosed |
| EP-2141712-A1 | ELECTROLYTE, AND ELECTROLYTE SOLUTION OR ELECTROCHEMICAL ELEMENT COMPRISING THE SAME | Sanyo Chemical Industries, Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100085683-A1 | ELECTROLYTE, ELECTROLYTIC SOLUTION, AND ELECTROCHEMICAL DEVICE USING THE SAME | HCN4, HCN1, HCN2 | CHRNA7 755/4885MEN1 2299/4885TSHR 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.