Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.73 |
| ▸ | SYK | P43405 | 11/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938207 | 0.90 | ROCK2 (0.78) | ROCK2ROCK1SYKMAPK8IRAK4 | |
| SCHEMBL1938209 | 0.90 | ROCK2 (0.78) | ROCK2ROCK1SYKMAPK8IRAK4 | |
| SCHEMBL1937783 | 0.87 | ROCK2 (0.69) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL1937784 | 0.87 | ROCK2 (0.69) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL3627383 | 0.85 | ROCK2 (0.79) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL3627381 | 0.85 | ROCK2 (0.79) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL1935855 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL1935856 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL12489141 | 0.85 | ROCK2 (0.83) | ROCK2ROCK1SYKMAPK8KIT | |
| SCHEMBL1937611 | 0.84 | ROCK2 (0.64) | ROCK2ROCK1SYKMAPK8KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |