Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.48 |
| ▸ | RAF1 | P04049 | 7/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | CDK8 | P49336 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MUSK | O15146 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623322 | 1.00 | KDR (0.48) | KDRRAF1RETFLT1BRAF | |
| SCHEMBL3553133 | 0.95 | KDR (0.49) | KDRRAF1RETFLT1BRAF | |
| SCHEMBL3553130 | 0.95 | KDR (0.49) | KDRRAF1RETFLT1BRAF | |
| SCHEMBL3541878 | 0.88 | LMNA (0.54) | KDRRAF1RETBRAFCDK8 | |
| SCHEMBL3541875 | 0.88 | LMNA (0.54) | KDRRAF1RETBRAFCDK8 | |
| SCHEMBL3543898 | 0.86 | CDK8 (0.51) | KDRRAF1BRAFCDK8MEN1 | |
| SCHEMBL3539800 | 0.86 | RAF1 (0.45) | KDRRAF1RETCDK8MEN1 | |
| SCHEMBL3539796 | 0.86 | RAF1 (0.45) | KDRRAF1RETCDK8MEN1 | |
| SCHEMBL3543897 | 0.86 | CDK8 (0.51) | KDRRAF1BRAFCDK8MEN1 | |
| SCHEMBL13547798 | 0.85 | BLM (0.44) | KDRRAF1RETCDK8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | claimed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652041-B2 | 4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridino-2-carboxamido: N-methyl-4-[4-(3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propyl)phenoxy]pyridine-2-carboxamide: Raf-kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |