Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361838 | 0.83 | CYP2D6 (0.55) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL3284976 | 0.79 | LMNA (0.55) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL362445 | 0.79 | LMNA (0.55) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL5502433 | 0.79 | LMNA (0.55) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL3711173 | 0.78 | LMNA (0.56) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL3471214 | 0.78 | LMNA (0.56) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL13388323 | 0.77 | TSHR (0.51) | TSHRCYP2D6LMNATDP1KDM4E | |
| SCHEMBL2163402 | 0.77 | MAP2K1 (0.55) | TSHRCYP2D6CHEK1SRC | |
| SCHEMBL3281444 | 0.77 | MAP2K1 (0.55) | TSHRCYP2D6CHEK1SRC | |
| SCHEMBL4088385 | 0.77 | SYK (0.59) | TSHRCYP2D6CHEK1SYKHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621482-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | Exelixis, Inc. (US) | 2013-08-07 | — | — | EP | disclosed |
| EP-2621483-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | Exelixis, Inc. (US) | 2013-08-07 | — | — | EP | disclosed |
| EP-2593091-A1 | C-MET MODULATOR PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012044574-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | EXELIXIS, INC. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012044577-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | EXELIXIS, INC. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012009723-A1 | C-MET MODULATOR PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |