Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303677 | 0.89 | PTGDR2 (0.40) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL305390 | 0.87 | PTGDR2 (0.39) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL1922279 | 0.85 | CCNT1 (0.43) | PTGDR2BRD4 | |
| SCHEMBL303566 | 0.84 | PTGDR2 (0.44) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL305283 | 0.84 | CCNT1 (0.40) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL302157 | 0.83 | PTGDR2 (0.39) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL305142 | 0.83 | MAPK14 (0.38) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL1922138 | 0.83 | LMNA (0.37) | PTGDR2LMNASMN1; SMN2JAK3JAK2 | |
| SCHEMBL305999 | 0.83 | CCNT1 (0.39) | PTGDR2JAK3JAK2KMT2ATP53 | |
| SCHEMBL303598 | 0.82 | BRD4 (0.47) | JAK3JAK2BRD9BRD4KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |