Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.66 |
| ▸ | ROS1 | P08922 | 1/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | TGM2 | P21980 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | TDO2 | P48775 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985676 | 0.88 | ACVR1 (0.83) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL18462586 | 0.88 | ACVR1 (0.83) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL31139641 | 0.84 | CES1 (0.77) | LRRK2CHEK1TGM2CES1IDO1 | |
| SCHEMBL8506968 | 0.83 | CHEK1 (0.65) | LRRK2ROS1CDK5ACVR1CHEK1 | |
| SCHEMBL3614440 | 0.83 | CHEK1 (0.81) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL14985677 | 0.81 | CSNK1G1 (0.77) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL25666640 | 0.81 | CSNK1G1 (0.67) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL9185276 | 0.80 | CSNK1G1 (1.00) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL2756784 | 0.78 | CSNK1G1 (0.63) | CSNK1G1LRRK2ROS1CDK5ACVR1 | |
| SCHEMBL3411665 | 0.77 | CHEK1 (0.67) | CSNK1G1LRRK2ROS1CDK5ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202989-B2 | One step process for the preparation of substituted 5, 10-dihydrodibenzo [b,e][1, 4]diazepine-11-ones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-06-19 | — | — | US | claimed |
| US-20100228023-A1 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2010-09-09 | — | — | US | claimed |
| US-8202989-B2 | One step process for the preparation of substituted 5, 10-dihydrodibenzo [b,e][1, 4]diazepine-11-ones | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-06-19 | — | — | US | disclosed |
| US-20100228023-A1 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228023-A1 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES | BBOX1, CYP1B1, CYP4B1 | CSNK1G1 2234/4885LRRK2 4616/4885ROS1 2526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.