Sugi Predict

Sugi Predict / Compounds / SCHEMBL362573

SCHEMBL362573

SCHEMBL362573

Cc1ccc(-c2nc3c(nc2-c2ccc(C)cc2)N(C(=O)OC(C)(C)C)C[CH][CH]3)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CKS1B P61024 2/20 0.39
▸ SKP1 P63208 2/20 0.39
▸ SKP2 Q13309 2/20 0.39
▸ GPR119 Q8TDV5 1/20 0.36
▸ TNK2 Q07912 1/20 0.35
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ ADRB2 P07550 1/20 0.34
▸ CNR1 P21554 2/20 0.34
▸ NR1H2 P55055 1/20 0.33
▸ MMP13 P45452 1/20 0.33
▸ GRM5 P41594 2/20 0.33
▸ KIT P10721 1/20 0.33
▸ GRM1 Q13255 1/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ KCNK3 O14649 3/20 0.32
▸ KCNK9 Q9NPC2 3/20 0.32
▸ KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL361636 0.91 CKS1B (0.47) CKS1BSKP1SKP2GPR119POLB
SCHEMBL363015 0.86 CKS1B (0.39) CKS1BSKP1SKP2GPR119TNK2
SCHEMBL361405 0.76 CKS1B (0.47) CKS1BSKP1SKP2GPR119POLB
SCHEMBL363069 0.74 CKS1B (0.39) CKS1BSKP1SKP2GPR119TNK2
SCHEMBL15110700 0.74 CKS1B (0.39) CKS1BSKP1SKP2GPR119TNK2
SCHEMBL15110209 0.74 CYP1A2 (0.39) CKS1BSKP1SKP2GPR119KMT2A
SCHEMBL15117344 0.74 GPR119 (0.37) CKS1BSKP1SKP2GPR119KMT2A
SCHEMBL15110449 0.73 GPR119 (0.41) CKS1BSKP1SKP2GPR119KMT2A
SCHEMBL361902 0.73 GPR119 (0.37) CKS1BSKP1SKP2GPR119KMT2A
SCHEMBL362961 0.72 GPR119 (0.41) CKS1BSKP1SKP2GPR119KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593452-B1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 2017-01-18 — — EP disclosed
US-9132127-B2 Substituted pyrido[2,3-B]pyrazines as IP receptor agonists NOVARTIS AG (CH) 2015-09-15 — — US disclosed
US-20140243346-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 2014-08-28 — — US disclosed
US-8754085-B2 Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist NOVARTIS AG (CH) 2014-06-17 — — US disclosed
EP-2593452-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS Novartis AG (CH) 2013-05-22 — — EP disclosed
US-20130102611-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 2013-04-25 — — US disclosed
WO-2012007539-A9 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 2012-11-01 — — WO disclosed
WO-2012007539-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS NOVARTIS AG (CH) 2012-01-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243346-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS PTGIR, ACVR1, PTGFR CKS1B 2862/4885SKP1 3883/4885SKP2 3562/4885
US-20130102611-A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS PTGIR, ACVR1, PTGFR CKS1B 2862/4885SKP1 3883/4885SKP2 3562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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