Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | PDE6A | P16499 | 1/20 | 0.34 |
| ▸ | PDE6G | P18545 | 1/20 | 0.34 |
| ▸ | PDE6B | P35913 | 1/20 | 0.34 |
| ▸ | PDE6C | P51160 | 1/20 | 0.34 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363762 | 0.91 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL364695 | 0.89 | PDE10A (0.53) | PDE10AHPGD | |
| SCHEMBL363354 | 0.88 | PDE10A (0.47) | PDE10AKDM4EPDE5APDE1BPDE4D | |
| SCHEMBL363269 | 0.84 | PDE10A (0.50) | PDE10AKDM4EHSD17B10MEN1RECQL | |
| SCHEMBL361381 | 0.82 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363739 | 0.81 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363853 | 0.80 | PDE10A (0.53) | PDE10AKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL371209 | 0.70 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363300 | 0.69 | PDE10A (0.68) | PDE10AKDM4EPDE5APDE1BPDE4D | |
| SCHEMBL259684 | 0.68 | PDE10A (0.46) | PDE10AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |