Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361381 | 0.94 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363354 | 0.91 | PDE10A (0.47) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL371209 | 0.89 | PDE10A (0.51) | PDE10AADORA1PDE5APDE1BPDE4D | |
| SCHEMBL363853 | 0.88 | PDE10A (0.53) | PDE10AAURKA | |
| SCHEMBL363269 | 0.86 | PDE10A (0.50) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363762 | 0.84 | PDE10A (0.51) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362601 | 0.81 | PDE10A (0.50) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL364695 | 0.79 | PDE10A (0.53) | PDE10AAURKA | |
| SCHEMBL363300 | 0.70 | PDE10A (0.68) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL260312 | 0.69 | PDE10A (0.45) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |