Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359395 | 0.90 | DRD2 (0.48) | SUV39H2DRD2POLBALDH1A1MAPT | |
| SCHEMBL357356 | 0.87 | DRD2 (0.52) | SUV39H2DRD2POLBKDM4EALDH1A1 | |
| SCHEMBL364706 | 0.84 | NOTUM (0.45) | POLBCHRM4KDM4EALDH1A1LMNA | |
| SCHEMBL14330897 | 0.81 | SIRT2 (0.41) | SIRT2SIRT1SIRT3SUV39H2DRD2 | |
| SCHEMBL14206418 | 0.80 | DRD2 (0.46) | SIRT2SIRT1SIRT3DRD2 | |
| SCHEMBL3957450 | 0.80 | DRD2 (0.43) | SIRT2SIRT1SIRT3DRD2ALDH1A1 | |
| SCHEMBL4437152 | 0.79 | POLB (0.48) | SUV39H2DRD2POLBKDM4EALDH1A1 | |
| SCHEMBL14206668 | 0.78 | SIRT2 (0.43) | SIRT2SIRT1SIRT3SUV39H2DRD2 | |
| SCHEMBL13419725 | 0.78 | SIRT2 (0.50) | SIRT2SIRT1SIRT3SUV39H2DRD2 | |
| SCHEMBL360125 | 0.77 | POLB (0.42) | POLBKDM4EALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |