Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | BLM | P54132 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GALK1 | P51570 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036770 | 0.69 | ADORA2A (0.58) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL28547676 | 0.68 | ADORA2A (0.48) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL10774439 | 0.68 | KDM4E (0.56) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL17343122 | 0.65 | KDM4E (0.56) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL31321152 | 0.65 | ROCK2 (0.46) | ADORA2AKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL6442955 | 0.65 | ADORA2A (0.64) | ADORA2AKDM4EHPGDALDH1A1POLB | |
| SCHEMBL3621162 | 0.63 | HTR2C (0.46) | — | |
| SCHEMBL13788691 | 0.63 | ADORA2A (0.46) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL16071244 | 0.63 | LRRK2 (0.54) | ADORA2AKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL2114203 | 0.63 | KDM4E (1.00) | ADORA2AKDM4EHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674907-B2 | Furanopyridine derivatives and methods of use | AMGEN INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | AMGEN INC. | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | LCK, NFATC1, MINK1 | ADORA2A 1232/4885KDM4E 2251/4885HPGD 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.