Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855843 | 0.81 | ALDH1A1 (0.50) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL5855805 | 0.81 | ALDH1A1 (0.50) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL5858394 | 0.81 | ALDH1A1 (0.50) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL5857277 | 0.81 | ALDH1A1 (0.50) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL21068275 | 0.80 | CYP4F2 (0.60) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL21068602 | 0.78 | MAPT (0.42) | MAPTABCC4ALDH1A1LPAR3LMNA | |
| SCHEMBL2784643 | 0.77 | PPARG (0.51) | MAPTLMNAPPARGPPARDPPARA | |
| SCHEMBL2784638 | 0.77 | PPARG (0.51) | MAPTLMNAPPARGPPARDPPARA | |
| SCHEMBL254199 | 0.76 | CYP4F2 (0.43) | CYP4F2CYP4A11PPARGPPARDPPARA | |
| SCHEMBL9623948 | 0.76 | TSHR (0.42) | MAPTABCC4ALDH1A1LPAR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033466-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE | PHENOMIX CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2010033466-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE | PHENOMIX CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |