Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 11/20 | 0.41 |
| ▸ | HTR2C | P28335 | 10/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400974 | 0.85 | PARP1 (0.47) | PARP1HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL11101784 | 0.83 | PARP1 (0.46) | PARP1HTR2BHTR2CHTR2A | |
| SCHEMBL2784144 | 0.83 | POLB (0.44) | PARP1MAPK1 | |
| SCHEMBL21614132 | 0.77 | PARP1 (0.59) | PARP1HTR2BHTR2CHTR2AHTR3E | |
| SCHEMBL30366187 | 0.77 | PARP1 (0.59) | PARP1HTR2BHTR2CHTR2AHTR3E | |
| SCHEMBL31227444 | 0.70 | PARP1 (0.45) | PARP1HTR2BHTR2CHTR2AHTR3E | |
| SCHEMBL31246891 | 0.70 | PARP1 (0.45) | PARP1HTR2BHTR2CHTR2AHTR3E | |
| Hydrochloric Acid SCHEMBL7496829 | 0.70 | HTR2C (0.47) | PARP1HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL7400024 | 0.70 | PARP1 (0.35) | PARP1 | |
| SCHEMBL20986525 | 0.70 | PARP1 (0.55) | PARP1HTR2BHTR2CHTR2AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795251-B2 | 3,4-dihydro-benzo[e][1,3]oxazin-2-ones | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | disclosed |
| EP-1874742-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | Novartis AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108671-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |