Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363433 | 0.82 | UHRF1 (0.46) | UHRF1KCNQ2FFAR1GRM5DYRK1A | |
| SCHEMBL4355540 | 0.82 | UHRF1 (0.54) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| Hydrochloric Acid SCHEMBL30527118 | 0.81 | UHRF1 (0.45) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| SCHEMBL6561559 | 0.80 | UHRF1 (0.41) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| SCHEMBL6561557 | 0.80 | UHRF1 (0.41) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| SCHEMBL14197632 | 0.80 | KCNQ2 (0.38) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| SCHEMBL4358691 | 0.78 | UHRF1 (0.50) | UHRF1KCNQ2FFAR1GSK3AGSK3B | |
| SCHEMBL13825233 | 0.78 | RECQL (0.53) | FFAR1GSK3AGSK3BNR3C2GRM5 | |
| SCHEMBL13824873 | 0.78 | NR3C2 (0.33) | NR3C2 | |
| SCHEMBL2170770 | 0.78 | PARP1 (0.38) | NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| US-5808101-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5710288-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-01-20 | — | — | US | disclosed |