Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | LOX | P28300 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17441423 | 0.89 | PARP1 (0.36) | PARP1KDM1AHDAC1HDAC6AR | |
| SCHEMBL1873732 | 0.82 | PARP1 (0.40) | PARP1KDM1AHDAC1HDAC6AR | |
| SCHEMBL3131775 | 0.81 | PARP1 (0.35) | PARP1KDM1AHDAC1HDAC6AR | |
| Bromide SCHEMBL2145632 | 0.81 | PARP1 (0.39) | PARP1KDM1AHDAC1HDAC6AR | |
| SCHEMBL362871 | 0.78 | UHRF1 (0.42) | NR3C2 | |
| SCHEMBL13824873 | 0.78 | NR3C2 (0.33) | NR3C2LOXL2 | |
| SCHEMBL13825233 | 0.78 | RECQL (0.53) | IDO1NR3C2LOXLOXL2 | |
| SCHEMBL2554810 | 0.77 | LOXL2 (0.57) | NR3C2LOXLOXL2 | |
| SCHEMBL17242282 | 0.76 | TDP1 (0.39) | PARP1KDM1AHDAC1HDAC6AR | |
| SCHEMBL30527951 | 0.76 | TDP1 (0.39) | PARP1KDM1AHDAC1HDAC6AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346868-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010036632-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| US-5808101-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5710288-A | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents | ALLERGAN (US) | 1998-01-20 | — | — | US | disclosed |