Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343277 | 1.00 | CCR5 (0.38) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL18790097 | 0.93 | CCR5 (0.40) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL2563376 | 0.93 | CCR5 (0.40) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL2586526 | 0.93 | CCR5 (0.40) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL18532541 | 0.93 | CCR5 (0.40) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL2579732 | 0.92 | CCR5 (0.39) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL17066435 | 0.89 | POLB (0.38) | CCR5ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL13060153 | 0.88 | GAA (0.40) | KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL20971890 | 0.87 | CCR5 (0.35) | CCR5PREPKMT2AHCRTR1HCRTR2 | |
| SCHEMBL20971889 | 0.87 | PREP (0.36) | CCR5PREPKMT2AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585064-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163640-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2011-12-29 | — | — | WO | disclosed |
| WO-2010075257-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2010-07-01 | — | — | WO | disclosed |