Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL596363 | 0.70 | ALDH1A1 (0.36) | MEN1KMT2AATMLMNA | |
| SCHEMBL2729762 | 0.68 | KCNJ1 (0.49) | KCNH2 | |
| SCHEMBL1977079 | 0.66 | KMT2A (0.77) | MEN1KMT2AATMLMNA | |
| SCHEMBL2548388 | 0.65 | HTR2A (0.60) | HTR2AHTR2CKCNH2 | |
| SCHEMBL27002802 | 0.65 | KCNA5 (0.51) | MEN1KMT2A | |
| SCHEMBL16795428 | 0.64 | KCNH2 (0.56) | MEN1KMT2AKCNH2 | |
| SCHEMBL620035 | 0.64 | GRIN2B (0.40) | — | |
| SCHEMBL5482230 | 0.64 | NOTUM (0.52) | KMT2ASMN1; SMN2TP53 | |
| SCHEMBL1514830 | 0.64 | HTR2A (0.58) | MEN1KMT2AATMHTR2AHTR2C | |
| SCHEMBL2927709 | 0.64 | MEN1 (0.73) | MEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155735-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008144222-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-11-27 | — | — | WO | disclosed |