Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.69 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.69 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630975 | 0.90 | HSP90AB1 (0.81) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3633945 | 0.88 | HSP90AB1 (0.53) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL8139380 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3632064 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3632853 | 0.85 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1747106 | 0.84 | HSP90AA1 (0.84) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3630178 | 0.83 | HSP90AB1 (0.88) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL1221000 | 0.83 | HSP90AB1 (0.82) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3631011 | 0.83 | HSP90AB1 (0.88) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL19629104 | 0.83 | HSP90AB1 (0.86) | HSP90AA1HSP90AB1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146967-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | Serenex, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008130879-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | SERENEX, INC. (US) | 2008-10-30 | — | — | WO | disclosed |