SCHEMBL3633945

SCHEMBL3633945

CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C#N)c(NC4CNCC(C(=O)OC(C)(C)C)C4)c3)c2C1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 16/20 0.53
HSP90AA1 P07900 15/20 0.53
HSP90B1 P14625 1/20 0.53
TRAP1 Q12931 1/20 0.53
OPRM1 P35372 2/20 0.39
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3629975 0.88 HSP90AA1 (0.69) HSP90AB1HSP90AA1HSP90B1TRAP1
SCHEMBL4380174 0.84 HSP90AB1 (0.58) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL3631636 0.83 HSP90AB1 (0.55) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL3631633 0.83 HSP90AB1 (0.55) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL4370532 0.83 HSP90AB1 (0.60) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL3633942 0.82 HSP90AB1 (0.53) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL5005577 0.82 HSP90AB1 (0.53) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL27196733 0.81 HSP90AB1 (0.61) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL1220779 0.80 HSP90AB1 (0.60) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1
SCHEMBL13740696 0.80 HSP90AB1 (0.65) HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2146967-A2 TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES Serenex, Inc. (US) 2010-01-27 EP disclosed
WO-2008130879-A2 TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES SERENEX, INC. (US) 2008-10-30 WO disclosed