Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.46 |
| ▸ | KDM5A | P29375 | 4/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 2/20 | 0.46 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29038570 | 0.98 | LMNA (0.56) | KDM4ELMNACYP3A4TSHRCYP1A2 | |
| SCHEMBL29038561 | 0.98 | LMNA (0.56) | KDM4ELMNACYP3A4TSHRCYP1A2 | |
| SCHEMBL3634347 | 0.95 | KDM4E (0.59) | KDM4ELMNACYP3A4TSHRCYP1A2 | |
| SCHEMBL17873933 | 0.89 | KDM4E (0.73) | KDM4ELMNACYP3A4TSHRCYP1A2 | |
| SCHEMBL28092824 | 0.86 | KDM5A (0.58) | KDM4ELMNACYP3A4TSHRKDM5B | |
| SCHEMBL2405138 | 0.85 | KDM4E (0.51) | KDM4ELMNACYP3A4TSHRCYP1A2 | |
| SCHEMBL31313484 | 0.84 | KDM5A (0.56) | KDM4ELMNACYP3A4TSHRKDM5B | |
| SCHEMBL3122441 | 0.84 | KDM5A (0.56) | KDM4ELMNACYP3A4TSHRKDM5B | |
| SCHEMBL31313418 | 0.84 | KDM5A (0.56) | KDM4ELMNACYP3A4TSHRKDM5B | |
| SCHEMBL29184940 | 0.84 | KDM5A (0.56) | KDM4ELMNACYP3A4TSHRKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |